Ionic, nonionic, cationic and amphoteric surfactants are well used for functionalization. Surface engineering of particles enhance the drug loading and drug release efficiency and also reduce the non-specific or unpleasant interaction with host. This also increases its biomedical applications. In order to load any drug onto SPIONs, it must be surface engineered or functionalized. To make the drug bioavailable at the target site, it is required to be loaded on a proper carrier like SPIONs. These incredible versatile properties of curcumin made the researchers to use it in drug delivery applications. Curcuminoids, which include curcumin related molecules, are effective antioxidants with demonstrated medicinal effects and as anticancer agent against various cancer types. The efficacy of curcumin for biological applications is studied in depth by many researchers. This might be due to poor absorption, rapid metabolism and rapid systemic elimination of curcumin. One of the deficiently bioavailable drugs, despite its varied cytotoxic effect, is curcumin. Hence, SPIONs have been raised to be one of the most important nanoparticles in industrial and biomedical research. Even more, using SPIONs, deficiently bioavailable drugs can be loaded and directed to the diseased location or site of action of the drug with the support of an external magnetic field, thus cross the limitations attributed by conventional therapeutic tools. SPIONs are the potent candidates as nanocarriers for targeted drug delivery as they are safe, obey external magnetic field and also allow fabrication and surface engineering. Most of the drugs have the issue of reaching the target site, which is overcome by advanced drug delivery of modern medicine wherein, targeted drug delivery is possible when proper nanocarrier is used. Superparamagnetic iron oxide nanoparticles (SPIONs) are believed to be one of the promising candidates for various biomedical applications such as imaging, diagnosis, drug carrier for targeted drug delivery and many others.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |